The Transcription Factor KLF2 Restrains CD4 + T Follicular Helper Cell Differentiation
نویسندگان
چکیده
منابع مشابه
The transcription factor KLF2 restrains CD4+ T follicular helper cell differentiation
T follicular helper (Tfh) cells are essential for efficient B cell responses, yet the factors that regulate differentiation of this CD4(+) T cell subset are incompletely understood. Here we found that the KLF2 transcription factor serves to restrain Tfh cell generation. Induced KLF2 deficiency in activated CD4(+) T cells led to increased Tfh cell generation and B cell priming, whereas KLF2 over...
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ژورنال
عنوان ژورنال: Immunity
سال: 2015
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2015.01.013